Cutaneous phototoxic reaction to intravenous micafungin in the outpatient setting: A case report

Signal Transducer and Activator of Transcription 1 (STAT1) Gain Function (GoF) mutations can predispose to chronic mucocutaneous candidiasis (CMC). Long term therapy with oral azole antifungals result in resistance the need treat alternatives such as echinocandins. A pan-azole-resistant Candida albicans was isolated from a mouth swab 39-year-old woman lifelong CMC. Her condition warranted systemic treatment this achieved through daily infusions micafungin, which patient self-administered at home within OPAT (Outpatient Parenteral Antimicrobial Therapy) service. The experienced good rapid clinical response. On day 18 developed an itchy rash presented back our hospital on 22. diagnosis phototoxic skin reaction, secondary established history, signs, investigations. Micafungin withdrawn reaction resolved without further intervention. maintained amphotericin lozenges. More research into potential micafungin its metabolites is needed but clinicians should remain aware phototoxicity individuals treated outpatient settings.